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INTRODUCTION: When the benefits of delivery outweigh continuation of pregnancy need for induction arises with the goal to achieve successful vaginal delivery within an acceptable time with minimum maternal side effects. AIMS AND OBJECTIVES: The study is designed to compare the effect of isosorbide mononitrate and prostaglandinE2 gel on cervical ripening. Administration of IMN is considered a low risk and relatively cheaper method of induction for pregnant women at term. MATERIAL AND METHODS: A randomized, comparative study was conducted to compare the efficacy of isosorbide mononitrate and prostaglandin E2 gel in cervical ripening and induction of labour.140 patients were randomly allocated into two groups, one group 70 patient received isosorbide mononitrate total 2 doses 12 hrs apart and the other group 70 patients received prostaglandinE2 maximum 3 doses 6hrs apart. Comparison of post induction bishops score, induction to delivery interval, number of vaginal delivery and neonatal outcome was done between both the groups. RESULTS: The mean post-induction Bishop score at 12 hours was higher in the PGE2 group (6.29?1.19) compared to IMN Group (3.67?1.10). The induction-to-delivery interval was longer in IMN Group (30.71?5.35hours) than in the PGE2 Group (13.48?1.81 hours). Vaginal delivery occurred in 71.4% (IMN) and 75.7% (PGE2) cases. Caesarean due to fetal distress was 5% (IMN) versus 47% (PGE2). Uterine Hyperstimulation was more frequent in PGE2 Group and incidence of headache was more in IMN group. CONCLUSION: IMN is effective and cheaper alternative to PGE2 for cervical ripening and induction of labour at term. Induction delivery interval is prolonged but it is convenient to use and well tolerated, It does not cause uterine hyperstimulation. Side effects like nausea, vomiting and palpitations are mild and not clinically significant. IMN can be self-administered vaginally at home or in OPD for cervical ripening in patient who are planned for induction.