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Introduction: Van Wyk Grumbach syndrome is a rare endocrine disorder presenting with hypothyroidism, precocious puberty, and ovarian cysts in girls, leading to significant health complications. Aims and Objectives: This case report aims to highlight the clinical features, diagnostic process, and management of Van Wyk Grumbach syndrome in a 12-year-old girl, emphasizing the need for timely recognition and treatment. Materials and Methods: A 12-year-old girl was assessed through clinical examination, laboratory tests for thyroid function, and imaging studies including wrist X-ray and pelvic ultrasound to evaluate her symptoms and hormonal status. Results: The patient exhibited severe anemia, elevated TSH, low T3 and T4 levels, delayed bone age, and bilateral polycystic ovaries. After blood transfusion and thyroid hormone replacement therapy, her symptoms improved significantly, indicating effective management of the syndrome. Conclusion: This case emphasizes the importance of early diagnosis and appropriate treatment for Van Wyk Grumbach syndrome, which can lead to significant recovery and improvement in the quality of life for affected patients.