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Title: "TAKAYASU ARTERITIS IN PREGNANCY: TYPES, OUTCOMES, AND MANAGEMENT STRATEGIES"

e-poster Number: EP 184

Category: Miscellaneous
Author Name: Dr. Angelin Vincy E
Institute: Christian medical college, vellore
Co-Author Name:
Abstract :
Background: Takayasu's arteritis (TA), which is also called young female arteritis, is a rare and chronic inflammatory disease mainly affecting the large vessels - aorta and its branches. 80- 90% of cases are seen in women and in the mean age of 10-40 years. The most serious complications are arterial occlusion and aneurysm formation in the large vessels. In pregnancy, the peak incidence is seen in the second and third trimesters and during labor and is mostly diagnosed only due to its complications. The types of Takayasu's arteritis are: - Type 1: Branches from the aortic arch - Type IIa: Ascending aorta, aortic arch and its branches - Type II b: Ascending aorta, aortic arch and its branches, thoracic descending aorta - Type III: Thoracic descending aorta, abdominal aorta, and/or renal arteries - Type IV: Abdominal aorta and/or renal arteries - Type V: Combined features of types IIb and IV Common complications seen during pregnancy are hypertension, organ dysfunction, fetal growth restriction, and low birth weight. Hence?interdisciplinary approach is required to optimize the care of such patients. Objective: To review the types of Takayasu arteritis, pregnancy outcomes in each type and management strategies. Methods: Retrospective case series of?pregnant women with Takayasu arteritis type I to V in a duration of 6 months and neonatal outcomes. Observations: Multidisciplinary team which included cardiology, Obstetrics, rheumatology, anaesthesia and neonatology departments were involved in the decision making and management. The patients were evaluated and the diagnosis was established with CT angiography which is the gold standard and stenting was done. The most common presentation was uncontrolled hypertension requiring more than 2 antihypertensives. Preterm delivery was warranted in view of superimposed pre- eclampsia and fetal growth restriction and also to prevent maternal complications like rupture of aortic aneurysm. One patient with type III had progressing fusiform aneurysm of descending thoracic aorta and upper abdominal aorta and hence termination of pregnancy was done. Contraception advise was given to all patients and counselled about optimization prior to next pregnancy. Conclusion: Takayasu arteritis types and pregnancy outcomes vary, but all require close monitoring and multidisciplinary management. Contraception until the disease activity is controlled,?Preconceptional counselling and individualized care plans can improve outcomes