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Introduction: Gestational Trophoblastic Disease (GTD) is a rare but serious condition with potential for invasive mole formation, leading to life-threatening hemorrhage and elevated Beta-HCG levels. Aims and Objectives: To evaluate the clinical presentation, diagnostic challenges, and management strategies in a patient with persistent GTD complicated by heavy bleeding and shock. Material and Methods: A 32-year-old female presented with heavy PV bleeding and shock. History of ? Vesicular mole with two D&C procedures for the same. Investigations included MRI pelvis, Beta-HCG levels, and ultrasonography. Emergency stabilization involved IV fluids and blood transfusions. Multidisciplinary care was provided for diagnosis confirmation and treatment planning. Results: Imaging revealed a bulky uterus with an invasive mole and probable arterio-venous fistula. Beta-HCG was 33,588 mIU/ml, confirming persistent GTD. Management included PCR transfusions, monitoring, and surgical intervention. Clinical improvement was achieved post-op with ongoing follow-up planned. Conclusions: This case emphasizes the importance of early diagnosis, multidisciplinary management, and tailored treatment for GTD. Timely stabilization and appropriate intervention can significantly reduce morbidity and improve outcomes in such high-risk cases.