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Genetic Association of AX1N1 gene polymorphism in ovarian cancer in North Indian Population Poonam Kashyap a M.D, , Sundeeep Singh Saluja b M.D, Dr Sangeeta Gupta c M.D ,Farah Parveen b Ph.D a,c Department of Obstetrics and Gynaecology, Maulana Azad Medical College, Delhi, 110002, India b,d Central Molecular Laboratory, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi 110002, India. Aim: The purpose of the present study is to investigate the association between the polymorphisms in AXIN1 with susceptibility to Epithelial ovarian carcinoma. Materials & methods: A total of 70 ovarian cancer patients and 70 healthy volunteers were recruited from Maulana Azad Medical College Delhi to participate in the study. Totally three tag single nucleotide polymorphisms in AXIN1 gene (rs12921862, rs1805105, rs370681) were genotyped using PCR & restriction fragment length polymorphism. Results: Significantly increased ovarian cancer risk was observed to be associated with the CT/CC genotypes of rs1805105 and AA genotype of rs12921862. Stratification analysis demonstrated that rs370681 polymorphism was related with high-grade ovarian cancer [p = 0.01, OR 95%CI = 4.50 (1.35-4.99)] and also with mucinous ovarian cancer. Kaplan?Meier survival curves showed that patients with rs12921862 C/C genotype improved overall survival in the EOC group. Conclusion: In conclusion our results suggested that rs1805105 CT/CC genotypes and rs12921862 AA genotype of AX1N1 gene may be susceptible for ovarian cancer development.