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Title: CHALLENGES IN THE MANAGEMENT OF ENDOMETRIAL CANCER AND ENDOMETRIAL HYPERPLASIA WITH ATYPIA IN SUB-FERTILE PATIENT: AN EMERGING MEDICAL ISSUE-OUR EXPERIENCE IN A TERTIARY CARE CENTRE

e-poster Number: EP 342

Category: Gynaecologic Oncology
Author Name: Dr. Nivedita Reshme
Institute: M.S.Ramaiah Medical College
Co-Author Name:
Abstract :
Introduction (30 words) The cases of endometrial hyperplasia with atypia/endometrial carcinoma with age below 40 years are rising and majority are nulliparous.Fertility preservation is feasible and consists of hormonal therapy mainly progestins . Aims & Objectives (40 words) In the present study we studied the oncological and obstetric outcomes of various fertility preserving treatment comprising a combination of oral progestins and levonorgestrol intra uterine device system (LNG-IUD)following the National Comprehensive Network criteria(NCCN) in majority of cases. Material & Methods (80 words) The study is a retrospective data analysis of patients visiting Bhagwan Mahaveer Jain Hospital (BMJH) between the period of January 2016 to January 2022 who were diagnosed with endometrial hyperplasia with atypia/endometrial carcinoma on endometrial biopsy and met the NCCN criteria (except 2 with myometrial invasion who were not willing for definitive surgery and wanted fertility preservation after taking detailed consent)were included.It has to be noted that molecular subtyping on the endometrial biopsy was done in the few recent patients. Results (80 words) Complete response was seen in 13 patients(76.47%), one patient showed no response and 3 had progressive disease(17.65%) with two cases having myometrial invasion on MRI at time of diagnosis. Five patients out of 13(13.46%) who had complete response initially had recurrence after 1-2 years out of which 3 had re-challenge with progestins with remission again. Pregnancy was achieved in 3 patients (23.07%) with complete response. Eight patients (61.54%) with complete response are doing well in follow up period. Conclusions (70 words) Levonorgestrol intra uterine system along with oral progestins is an effective combination as device might be useful in optimising the dose of oral progestins.Individually they should be continued in responders till conception as maintenance therapy. Hysterectomy should be advised if hormonal treatment fails or after completion of childbearing. Myometrial invasion may not be absolute contraindication for above treatment.Molecular profiling of endometrial biopsy might help in better prognostication and treatment strategy.