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Introduction In Abnormal uterine bleeding detection of uterine artery doppler velocimetric indices measurement as a non-invasive screening tool to detect endometrial pathology in women with peri and post-menopausal bleeding to distinguish benign endometrium from malignant or premalignant endometrium. Objectives: To evaluate the role of uterine artery doppler velocimetric indices (RI and PI) as a non-invasive screening procedure to detect endometrial pathology with peri and post-menopausal bleeding. To correlate the ultrasonographic results with histopathological findings in normal and pathological endometrium. Methodology: This prospective observational study of 222 patients was conducted in the OBG department at our Institute. We recruited 160 perimenopausal women with abnormal uterine bleeding and 62 were postmenopausal women with postmenopausal bleeding. Patients were initially screened with transvaginal ultrasound for endometrial thickness, morphology and Doppler indices were obtained from the uterine artery (Resistance index and the Pulsatility index). These results were compared to the histopathological findings, to draw a correlation. Results: The RI and PI values were found to be higher in benign endometrium as compared to pre-malignant/malignant endometrium due to increase in blood flow in malignant endometrium and decrease in vascular impedance. The mean RI at 0.535 by AUROC, sensitivity of 42.9%, specificity of 99.5%, PPV of 75%, NPV of 98% and diagnostic accuracy of 97.6%. The mean PI at 1.995 by AUROC, sensitivity of 57.1%, specificity of 82.1%, PPV of 10%, NPV of 98.2% and diagnostic accuracy of 81.2%. Conclusion: In perimenopausal and postmenopausal women with abnormal uterine bleeding, uterine artery doppler velocimetry is an easy, cost effective, non-invasive screening tool to distinguish benign endometrium from malignant or premalignant endometrium and combined with TVS to increase the screening accuracy and decrease the false results .In conjunction with histopathological examination which is gold standard to detect the type of endometrial abnormality, is confirmatory.