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Title: HEMOLYTIC DISEASE OF THE NEWBORN DUE TO ANTI-C ISOIMMUNIZATION: A CASE REPORT
e-poster Number: EP 474
Category: Sexual and Reproductive Health and Rights and Contraception
Author Name: Dr. Richa Dhirawani
Institute: Jabalpur Hospital and Research Centre
Co-Author Name:
Abstract :
The Rhesus (Rh) blood group is one of the most complex blood groups known in humans. Anti-D causes the most severe form of hemolytic disease of the newborn(HDN). Other Rh allo antibodies that are capable of causing severe HDN include Anti-c, which clinically is the most important Rh antigen after the D antigen. We report a case of hemolytic disease of the newborn due to Rh anti-c in an infant of an Rh positive mother. A G2P1L1 with full term pregnancy with previous LSCS was referred to our centre for anemia management and delivery. We could not match the blood group for cross match of the mother . Under hematologist supervision, IV steroids were given, even O negative blood group couldn?t cross match.A 2.5 kg baby was delivered by LSCS in view of fetal distress. Baby was limp with severe bradycardia kept on ventilator for 4days then weaning done shifted to CPAP for 5days followed by nasal oxygen for 7days. The baby?s blood group was A positive. Mother?s blood group was AB positive Baby developed thrombocytopenia for which blood sample sent for cross matching with same blood group as baby's but couldn't cross match1 unit platelet from "O"RH-ve blood group donor transfusion done to baby. In view of the persistent anaemia and hyperbilirubinemia, the blood was tested for atypical antibodies. Anti-c antibodies were found to be positive. The baby was treated with immunoglobulins and phototherapy. The baby recovered and was discharged on 18th day. This report aims to raise awareness about the rare but potentially life-threatening condition of anti-C isoimmunization-induced HDN.
