Welcome to the ePoster Viewing Panel of AICOG 2025

Toxoplasmosis in pregnancy Introduction- Toxoplasmosis is caused by ubiquitous protozoan parasite Toxoplasma Gondii It is generally asymptomatic disease. Primary Maternal infection during Pregnancy can be transmitted to the foetus and results in serious sequelae and major congenital malformations, intrauterine death and severe genetic abnormalities in the newborn MATERIALS AND METHODS 23 years old G3P1L0A1 with 34 WEEKS OF GESTATION WITH KNOWN CASE OF HYPOTHYROIDISM admitted to Bapuji hospital i/v/o decreased perception of foetal movements. ON EXAMINATION VITALS STABLE NO PALLOR, General Physical Examination found to be normal, CVS /RS- NAD PER ABDOMEN- UTERUS 28 TO 30 WEEK SIZE Clinically Less Liquor PRESENT, BREECH AT LOWER POLE FHS ? present/ regular/ 120-126bpm ROUTINE ANTENATAL INVESTIGATIONS WERE NORMAL interval growth scan: It shows dilatation of 3rd and 4th ventricles with periventricular calcifications f/s/o CMV infection with pericardial effusion with Stage 1 IUGR Torch screening test: IGM ANTIBODIES Positive for toxoplasmosis, MANAGEMENT AND RESULTS Patient was planned for induction of labour i/v/o stage 1 FGR was induced with TAB. Mifepristone 200MG STAT followed by Foley's bulb and Cervi prime gel to deliver a S/L/PT MALE baby of b.wt 1.56 kg @5.15pm on 12/06/2024, baby was resuscitated FOLLOWING DELIVERY i/v/o of poor APGAR score but baby couldn't be reviewed even after 10mins of resuscitation and declared dead. Due to PREVIOUS HISTORY OF 1st trimester abortion FOLLOWING A fever EPISODE AND HISTORY OF STILL BIRTH in previous pregnancy, Dead FETUS WAS sent to PATHOLOGICAL AUTOPSIC examination and chromosomal micro array analysis Pathological autopsy examination of dead neonate shows pericardial effusion and dilated chambers of the heart and unilateral undescended testes Chromosomal microarray analysis of dead neonate shows Uniparental Disomy common imprinting disorders associated with this genetic abnormality include Russell-silver syndrome, familial non chromatin Gan glioma, temple syndrome, precocious puberty syndrome, Angelman syndrome CONCLUSION Diagnosis of Maternal Toxoplasmosis during pregnancy is based on seroconversion in Pregnancy and Anti TOXOPLASMA GONDII Ig M AND Ig G antibodies and Amniotic Fluid survey for Toxoplasma gondii specific DNA BY PCR METHOD FOR FEMALES PLANNING FOR PREGNANCY and who are pregnant It is recommended to avoid risky behaviours such as eating raw or under cooked meat vertical transmission Risks of intracranial lesions and neuro developmental sequelae increases with gestational age in pregnancy