Welcome to the ePoster Viewing Panel of AICOG 2025

TITLE: Comparison of Intramuscular carbetocin versus oxytocin for the prevention of postpartum hemorrhage following vaginal delivery INTRODUCTION: Post-partum haemorrhage is still a leading and preventable cause of maternal death in India. Oxytocin is widely used uterotonic agent, But having shorter half-life and heat sensitive nature it can be ineffective. Carbetocin is a synthetic, heat stable, long-lasting oxytocin agonistic analogue with prolonged half-life may theoretically offer advantages over oxytocin in the management of the third stage of labor and can be effective alternative to oxytocin . AIMS AND OBJECTIVES: To compare the effectiveness of carbetocin versus oxytocin for the prevention of postpartum haemorrhage following delivery on following parameters, total amount of blood loss, time for placental separation, if manual or surgical removal of placenta, amount of blood loss after placental separation, need for additional uterotonic agent, difference between blood haemoglobin level before delivery and 24 hrs after delivery? MATERIAL METHODS: Comparative prospective randomised control trial conducted on total 200 patients.100 Women in each group randomly assigned to receive 100mcg single intramuscular injection of heat stable carbetocin (group A) or oxytocin at 10 IU(group B) immediately after the birth of baby. Total blood loss postpartum, need for other uterotonics , need for surgical or manual removal of placenta, side effects of drugs, pre and post-delivery CBC after 24 hours were compared RESULTS: Estimated mean blood loss, mean drop in haemoglobin in carbetocin group was significantly less compared to oxytocin group and the difference was statistically significant. Both the drug were well tolerated and there was no difference in duration of placental separation or placental separation complications. CONCLUSION: Single dose of intramuscular carbetocin 100 ?g may be more effective as compared to a single intramuscular 10 u dose of oxytocin in reducing postpartum blood loss following vaginal delivery. Heat stable carbetocin can be used over heat sensitive oxytocin in active management of third stage of labour following vaginal delivery.