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SHINE THE LIGHT ON SICKLE CELLS- A MARVEL MEMOIR THAT CROSSED HURDLES TO SUCCEED INTRODUCTION Sickle cell hemoglobinopathies encompasses a qualitative and quantitative genetically inherited hemoglobin disorders.The physiological changes in pregnancy predispose to an increased risk of catastrophic events like vaso-occlusive crisis, thromboembolic events leading eventually to a compromised uteroplacental circulation. AIMS AND OBJECTIVES To highlight the importance of haemoglobinopathies complicating pregnancy and the involvement of multidisciplinary team in managing such high risk obstetric conditions in providing a favourable maternal and fetal outcome.To effectively assess the anaemia in pregnancy to include a wide differential diagnosis that might require different management strategies. MATERIALS AND METHODS A 21 years old short Primigravida diagnosed to be case of Sickle cell disease at her six years of age attended our OPD at 37weeks of gestation for safe confinement.On admission she had moderate anaemia and was transfused with 1 unit PRBC.She was under the regular follow up of our Haematology department since diagnosis with repeated blood transfusions and had prophylactic pneumococcal and meningococcal vaccines.She was started on Inj.LMWH and tab Aspirin due to her pregnancy to combat the thromboembolic phenomenon she may develop in the due course.Five days after her admission,she developed acute pain crisis being managed in our high dependency unit with the guidance of anaesthesiologists and haematologists.Her pain crisis resolved after two days.Splenomegaly was evident with normal echocardiography.She was taken up for Elective LSCS in view of CPD Major and she delivered an alive baby.She was restarted on Inj.LMWH and Tab Aspirin and discharged with regular follow up further RESULTS Strengthening antenatal care is associated with blood investigations for every registered antenatal patient with adequate awareness about the condition that precipitate the crisis.The case of our interest was delivered safely beyond obstacles and the neonate was also screened for Sickle cell disease and was under observation in NICU for first few days of life.The mother was discharged with haematologist and rheumatologist review.The role of multidisciplinary team is always essential and everyone must be informed priorly when such a case is being managed in our set up CONCLUSION Pregnant patients with SCD have an increased risk of maternal and perinatal complications, including death.?Patients with SCD should be supported in making an informed decision regarding their reproductive options in a shared decision-making process in consultation with maternal-fetal medicine (MFM) subspecialists and hematologists with expertise in SCD. Prepregnancy counseling allows a patient with SCD the opportunity to make an informed decision regarding pregnancy. A multidisciplinary team should outline a plan of care acknowledging that under-anticoagulation could lead to a life-threatening embolus and that over-anticoagulation could lead to a hemorrhagic stroke. Late preterm or early-term delivery may be considered in patients with SCD to reduce the risk of preeclampsia, sudden labile BP spikes, and risk of hemorrhagic stroke and death.?