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AIM and Objective To evaluate IVF outcome after transfer of a blastocyst cultured from vitrified thawed cleavage embryos (VTCE) compared with conventional frozen thawed blastocyst transfer (FBT). To assess the clinical pregnancy rate, implantation rate and abortion rate between the two groups. Introduction The use of blastocyst culture and transfer is viewed as an effective method, offering several benefits like improved synchronization between the embryo and endometrium, higher pregnancy rates, increased implantation rates, reduced risk of multiple pregnancies, and higher live birth rates. Some centers have specific work practices freezing of cleavage embryos in fresh cycles and subsequent transfer of blastocysts cultured from these thawed cleavage embryos (VTCE). Thus, this study aimed to compare the clinical outcomes of VTCE Blastocyst transfer with conventional frozen thawed blastocyst transfer (FBT). Methodology This analysis is a retrospective study of total 158 patients undergoing Blastocyst transfer from January 2023 to December 2023. The rates of clinical pregnancy, implantation and early miscarriages were compared after transfer of Blastocyst derived from vitrified thawed cleavage embryos (VTCE) 76 patients and frozen thawed blastocyst (FBT) 82 patients at two different centers. Results The clinical pregnancy rate was higher 53.94 % in VTCE group than FBT group 43.90 % of all ET patients and (83% ,75%) as CPR of positive beta HCG respectively. VTCE blastocyst transferred resulted in a lower risk of early miscarriages (17% versus 25%). No significant difference was found regarding Implantation rate 30.61% in VTCE group compared to FBT group 29.55 % but there was significant difference in multiple pregnancy rate 25% in FBT group versus 9.7% in VTCE group. Conclusion This study suggest extended culture of frozen thaw cleavage embryos can be an alternative option to conventional FBT and can be considered as a practice model that includes freezing cleavage embryos in fresh cycles and subsequent transfer of blastocysts cultured from these thawed cleavage embryos for better outcomes